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Protein Coding Gene : P2rx4 purinergic receptor P2X, ligand-gated ion channel 4
Primary Identifier  MGI:1338859 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  18438
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables extracellularly ATP-gated monoatomic cation channel activity. Acts upstream of or within several processes, including excitatory postsynaptic potential; nitric oxide biosynthetic process; and vasodilation. Located in apical part of cell. Is active in lysosomal membrane. Is expressed in several structures, including cardiovascular system; gut; immune system; nervous system; and viscerocranium. Orthologous to human P2RX4 (purinergic receptor P2X 4).
PHENOTYPE: Homozygous mutation of this gene results in hypertension, abnormal artery morphology, abnormal nitric oxide homeostasis, and impaired flow induced vascular remodeling and vasodilation. [provided by MGI curators]
  • synonyms:
  • P2rx4,
  • expressed sequence AI504491,
  • DNA segment, Chr 5, ERATO Doi 444, expressed,
  • MGI:1196264,
  • D5Ertd444e,
  • MGI:2140926,
  • purinergic receptor P2X, ligand-gated ion channel 4,
  • P2X4,
  • expressed sequence AW555605,
  • MGI:2141234,
  • AW555605,
  • AI504491
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Features --> Cross References

Genome

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0 Canonical

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2 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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