| Primary Identifier | IPR033837 | Type | Domain |
| Short Name | UCH37 |
| description | The ubiquitin C-terminal hydrolase (UCH; ubiquitinyl hydrolase; ubiquitin thiolesterase; MEROPS family C12) family of deubiquitinating enzymes (DUBs) consists of several members including: UCH-L1, UCH-L3, UCH-L5 (UCH37) and BRCA1-associated protein-1 (BAP1), all containing a conserved catalytic domain with cysteine peptidase activity []. UCH-L5 (UCH37; MEROPS identifier C12.005) is involved in the deubiquitinating activity in the 19S proteasome regulatory complex. It is also associated with the human Ino80 chromatin-remodeling complex (hINO80) in the nucleus []. UCH-L5 specifically cleaves 'Lys-48'-linked polyubiquitin chains []. |
