| Primary Identifier | IPR032927 | Type | Family |
| Short Name | Erbin |
| description | Erbin (also known as Protein LAP2), was first identified as an adaptor for the receptor ERBB2/HER2 in epithelia []. It is involved in inhibition of several intracellular signalling pathways, such as Ras-mediated activation of extracellular signal-regulated kinase (ERK), nuclear factor kappaB, and transforming growth factor beta signalling pathways [].It contains an N-terminal domain with 16 leucine-rich repeats and a C-terminal PDZ domain. Through its amino-terminal region, Erbin disrupts Ras-Raf interaction by preventing the Ras-binding protein Shoc2 from binding to Ras, and thus acting as a tumour suppressor []. |
