| First Author | Wang G | Year | 2008 |
| Journal | J Natl Cancer Inst | Volume | 100 |
| Issue | 24 | Pages | 1815-7 |
| PubMed ID | 19066276 | Mgi Jnum | J:142676 |
| Mgi Id | MGI:3821944 | Doi | 10.1093/jnci/djn385 |
| Citation | Wang G, et al. (2008) DNA structure-induced genomic instability in vivo. J Natl Cancer Inst 100(24):1815-7 |
| abstractText | Noncanonical DNA structures are postulated to be responsible for some breakpoint hotspots that occur frequently in cancers. We developed a novel mouse model system using the naturally occurring H-DNA structure that deviate from the familiar right-handed helical B form found at the breakage hotspot in the human c-MYC promoter and a Z-DNA-forming CG repeat to test this idea directly. Large-scale chromosomal deletions and/or translocations occurred in 5 (7.7%, 95% confidence interval [CI] = 3.7% to 12.8%) of the 65 mice carrying the H-DNA-forming sequences and in 7 (6.6%, 95% CI = 3.8% to 11.6%) of the 106 mice carrying the Z-DNA-forming sequences, but in 0 of the 63 control mice (P = .042 and P = .035, respectively, two-sided test). Thus, the DNA structure itself can introduce instability in a mammalian genome. |
