Primary Identifier | MGI:1856167 | Allele Type | Radiation induced |
Gene | Kitl | Inheritance Mode | Semidominant |
Strain of Origin | (C3H/HeH x 101/H)F1 x STOCK Gdf5<bp> Myo5a<d> Bmp5<se> Hps6<ru> Hps1<ep> | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Karyotypic analysis revealed an ~40 cM paracentric inversion with the proximal breakpoint at the junction of bands 10B1/10B2 and the distal break at the junction of bands 10C2/10C3. The inversion is 115 kb 5' of the Kitl coding sequence. Northern analysis shows normal transcript size but this allele exerts tissue-specific reduction in Kitl mRNA expression. |