| First Author | Varona R | Year | 1998 |
| Journal | FEBS Lett | Volume | 440 |
| Issue | 1-2 | Pages | 188-94 |
| PubMed ID | 9862452 | Mgi Jnum | J:51311 |
| Mgi Id | MGI:1315086 | Doi | 10.1016/s0014-5793(98)01450-1 |
| Citation | Varona R, et al. (1998) Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha. FEBS Lett 440(1-2):188-94 |
| abstractText | We have cloned the murine CCR6 receptor and its ligand, the beta-chemokine mMIP-3alpha. Calcium mobilization assays performed with mCCR6 transfectants showed significant responses upon addition of mMIP-3alpha. Murine MIP-3alpha RNA is expressed in thymus, small intestine and colon, whereas mCCR6 RNA is expressed in spleen and lymph nodes. RT-PCR analysis of FACS-sorted lymphoid and antigen presenting cell subsets showed mCCR6 expression mainly in B cells, CD8- splenic dendritic cells and CD4+ T cells. The cloning and functional characterization of the mCCR6 and mMIP-3alpha will allow the study of the role of these proteins in mouse models of inflammation and immunity. |
