| First Author | Kovalchuk AL | Year | 2000 |
| Journal | J Exp Med | Volume | 192 |
| Issue | 8 | Pages | 1183-90 |
| PubMed ID | 11034608 | Mgi Jnum | J:65245 |
| Mgi Id | MGI:1913241 | Doi | 10.1084/jem.192.8.1183 |
| Citation | Kovalchuk AL, et al. (2000) Burkitt lymphoma in the mouse. J Exp Med 192(8):1183-90 |
| abstractText | Chromosomal translocations juxtaposing the MYC protooncogene with regulatory sequences of immunoglobulin (Ig) H chain or kappa (Igkappa) or lambda (Iglambda) L chain genes and effecting deregulated expression of MYC are the hallmarks of human Burkitt lymphoma (BL). Here we report that lymphomas with striking similarities to BL develop in mice bearing a mutated human MYC gene controlled by a reconstructed Iglambda locus encompassing all the elements required for establishment of locus control in vitro. Diffusely infiltrating lymphomas with a typical starry sky appearance occurred in multiple founders and an established line, indicating independence from positional effects. Monoclonal IgM(+)CD5(-)CD23(-) tumors developed from an initially polyclonal population of B cells. These results demonstrate that the phenotype of B lineage lymphomas induced by MYC dysregulation is highly dependent on cooperativity among the regulatory elements that govern expression of the protooncogene and provide a new system for studying the pathogenesis of BL. |
