| First Author | Kawagoe T | Year | 2008 |
| Journal | Nat Immunol | Volume | 9 |
| Issue | 6 | Pages | 684-91 |
| PubMed ID | 18438411 | Mgi Jnum | J:136290 |
| Mgi Id | MGI:3795833 | Doi | 10.1038/ni.1606 |
| Citation | Kawagoe T, et al. (2008) Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat Immunol 9(6):684-91 |
| abstractText | Members of the IRAK family of kinases mediate Toll-like receptor (TLR) signaling. Here we show that IRAK2 was essential for sustaining TLR-induced expression of genes encoding cytokines and activation of the transcription factor NF-kappaB, despite the fact that IRAK2 was dispensable for activation of the initial signaling cascades. IRAK2 was activated 'downstream' of IRAK4, like IRAK1, and TLR-induced cytokine production was abrogated in the absence of both IRAK1 and IRAK2. Whereas the kinase activity of IRAK1 decreased within 1 h of TLR2 stimulation, coincident with IRAK1 degradation, the kinase activity of IRAK2 was sustained and peaked at 8 h after stimulation. Thus, IRAK2 is critical in late-phase TLR responses, and IRAK1 and IRAK2 are essential for the initial responses to TLR stimulation. |
