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Allele : Atp1a2<tm3Ling> ATPase, Na+/K+ transporting, alpha 2 polypeptide; targeted mutation 3, Jerry B Lingrel

Primary Identifier  MGI:3027260 Allele Type  Targeted
Gene  Atp1a2 Transmission  Germline
Strain of Origin  129S6/SvEvTac Is Recombinase  false
Is Wild Type  false
molecularNote  Two missense mutations (L111R and N122D) were engineered into exon 4. A floxed neo cassette included in the targeting vector was excised from intron 3 prior to germline transmission. The mutations, which manifest in the first extracellular domain of the alpha 2 isoform, impair cardiac glycoside affinity. Western blot analysis of mutant mice indicated that the mutations did not affect either the level protein expression or the distribution of the alpha 1 and alpha 3 isoforms.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • alpha2<R>,
  • alpha2<R>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

21 Publication categories

Trail: Allele