| First Author | Morito N | Year | 2006 |
| Journal | Cancer Res | Volume | 66 |
| Issue | 2 | Pages | 812-9 |
| PubMed ID | 16424013 | Mgi Jnum | J:106513 |
| Mgi Id | MGI:3618680 | Doi | 10.1158/0008-5472.CAN-05-2154 |
| Citation | Morito N, et al. (2006) Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human. Cancer Res 66(2):812-9 |
| abstractText | c-Maf translocation or overexpression has been observed in human multiple myeloma. Although c-maf might function as an oncogene in multiple myeloma, a role for this gene in other cancers has not been shown. In this study, we have found that mice transgenic for c-Maf whose expression was direct to the T-cell compartment developed T-cell lymphoma. Moreover, we showed that cyclin D2, integrin beta(7), and ARK5 were up-regulated in c-Maf transgenic lymphoma cells. Furthermore, 60% of human T-cell lymphomas (11 of 18 cases), classified as angioimmunoblastic T-cell lymphoma, were found to express c-Maf. These results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin beta(7), might be downstream target genes of c-Maf leading to malignant transformation. |
