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Protein Coding Gene : Mapk14 mitogen-activated protein kinase 14

Primary Identifier  MGI:1346865 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  26416
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables MAP kinase activity and NFAT protein binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of cell differentiation; and skeletal system development. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of macromolecule biosynthetic process. Located in mitochondrion; nucleus; and spindle pole. Is active in cytosol and glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; head mesenchyme; and telencephalon. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14).
PHENOTYPE: Mice homozygous for various null mutations are embryonic to perinatal lethal showing multiple organ system defects. Mice homozygous for a knock-out mutation exhibit abnormal myoblast differentiation and delayed myofiber growth and maturation. [provided by MGI curators]
  • synonyms:
  • p38,
  • Csbp1,
  • CSBP2,
  • p38 MAP kinase alpha,
  • p38a,
  • MGI:1338028,
  • cytokine suppressive anti-inflammatory drug binding protein 1,
  • Crk1,
  • p38 MAP Kinase,
  • p38-alpha,
  • Mapk14,
  • p38 alpha,
  • p38MAPK,
  • MGI:88502,
  • mitogen-activated protein kinase 14,
  • CDC2-related kinase 1,
  • p38alpha,
  • MGD-MRK-2145,
  • Mxi2,
  • p38 MAPK

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

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0 Involved In Mutations

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0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

64 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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0 Driver For