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Protein Coding Gene : Chrna6 cholinergic receptor, nicotinic, alpha polypeptide 6
Primary Identifier  MGI:106213 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  11440
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within membrane depolarization and regulation of dopamine secretion. Located in presynapse. Part of acetylcholine-gated channel complex. Is active in dopaminergic synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
PHENOTYPE: Homzygous mutant animals have decreased numbers of high affinity binding sites for [3H]nicotine, [3H]epibaditine, and [3H]cytisine in the terminal region of the retinal ganglion. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-33905,
  • alpha6 nAChR,
  • Acra6,
  • acetylcholine receptor alpha 6 neural,
  • Chrna6,
  • cholinergic receptor, nicotinic, alpha polypeptide 6
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Involved In Mutations

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1 Transgenic Expressors

Trail: ProteinCodingGene

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

8 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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2 Driver For

Trail: ProteinCodingGene




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