| Primary Identifier | MGI:97596 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 18751 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables calcium channel regulator activity and diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; and positive regulation of cell communication. Acts upstream of or within calcium ion transport; cellular response to carbohydrate stimulus; and intracellular calcium ion homeostasis. Located in cytoplasm and nucleus. Part of spectrin. Is active in calyx of Held; plasma membrane; and presynaptic cytosol. Is expressed in several structures, including central nervous system; exocrine system; genitourinary system; heart ventricle; and retina. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). PHENOTYPE: Mice homozygous for a null allele exhibit impaired humoral immune responses, altered proliferative responses of B cells to various stimuli, abnormal vascular wound healing, and deficits in contextual and cued fear conditioning. ENU-induced mutations leadto impaired T cell-independent IgM responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
