| First Author | Hayasaka K | Year | 1993 |
| Journal | Genomics | Volume | 17 |
| Issue | 3 | Pages | 755-8 |
| PubMed ID | 7503936 | Mgi Jnum | J:14536 |
| Mgi Id | MGI:62701 | Doi | 10.1006/geno.1993.1400 |
| Citation | Hayasaka K, et al. (1993) Structure and chromosomal localization of the gene encoding the human myelin protein zero (MPZ). Genomics 17(3):755-8 |
| abstractText | We describe the cloning, characterization, and chromosomal mapping of the human myelin protein zero (MPZ) gene. The gene is about 7 kb long and consists of six exons corresponding to the functional domains. All exon-intron junction sequences conform to the GT/AG rule. The 5'-flanking region of the gene has a TA-rich element (TATA-like box), two CAAT boxes, and a single defined transcription initiation site detected by the primer extension method. The gene for human MPZ was assigned to chromosome 1q22-q23 by spot blot hybridization of flow-sorted human chromosomes and fluorescence in situ hybridization. The localization of the MPZ gene coincides with the locus for Charcot-Marie-Tooth disease type 1B, determined by linkage analysis. |
