| First Author | Moriyama M | Year | 2011 |
| Journal | J Neurosci | Volume | 31 |
| Issue | 11 | Pages | 3981-9 |
| PubMed ID | 21411641 | Mgi Jnum | J:170456 |
| Mgi Id | MGI:4946536 | Doi | 10.1523/JNEUROSCI.3617-10.2011 |
| Citation | Moriyama M, et al. (2011) Complement Receptor 2 Is Expressed in Neural Progenitor Cells and Regulates Adult Hippocampal Neurogenesis. J Neurosci 31(11):3981-3989 |
| abstractText | Injury and inflammation are potent regulators of adult neurogenesis. As the complement system forms a key immune pathway that may also exert critical functions in neural development and neurodegeneration, we asked whether complement receptors regulate neurogenesis. We discovered that complement receptor 2 (CR2), classically known as a coreceptor of the B-lymphocyte antigen receptor, is expressed in adult neural progenitor cells (NPCs) of the dentate gyrus. Two of its ligands, C3d and interferon-alpha (IFN-alpha), inhibited proliferation of wild-type NPCs but not NPCs derived from mice lacking Cr2 (Cr2(-/-)), indicating functional Cr2 expression. Young and old Cr2(-/-) mice exhibited prominent increases in basal neurogenesis compared with wild-type littermates, whereas intracerebral injection of C3d resulted in fewer proliferating neuroblasts in wild-type than in Cr2(-/-) mice. We conclude that Cr2 regulates hippocampal neurogenesis and propose that increased C3d and IFN-alpha production associated with brain injury or viral infections may inhibit neurogenesis. |
