| First Author | Wallrapp C | Year | 1998 |
| Journal | FEBS Lett | Volume | 440 |
| Issue | 3 | Pages | 387-92 |
| PubMed ID | 9872408 | Mgi Jnum | J:64917 |
| Mgi Id | MGI:1890121 | Doi | 10.1016/s0014-5793(98)01492-6 |
| Citation | Wallrapp C, et al. (1998) The product of the mammalian orthologue of the Saccharomyces cerevisiae HBS1 gene is phylogenetically related to eukaryotic release factor 3 (eRF3) but does not carry eRF3-like activity. FEBS Lett 440(3):387-92 |
| abstractText | We describe here the cloning and sequencing of human and mouse cDNAs encoding a putative GTP binding protein. Sequence comparison shows that these cDNAs (named eRFS) are likely to represent the orthologues of the yeast Saccharomyces cerevisiae HBS1 gene and that the C-terminal domains of the encoded proteins share structural features with eukaryotic elongation factor eEF-1A and release factor 3 (eRF3) families. The phylogenetic analysis suggests that eRFS proteins and Hbs1p form a cluster of orthologous sequences branching with the eRF3 family. Nevertheless, in yeast, the human eRFS protein and Hbs1p do not complement eRF3/Sup35p thermosensitive mutation and do not interact with eRF1. |
