| First Author | Hwang ES | Year | 2005 |
| Journal | Science | Volume | 307 |
| Issue | 5708 | Pages | 430-3 |
| PubMed ID | 15662016 | Mgi Jnum | J:245321 |
| Mgi Id | MGI:5917559 | Doi | 10.1126/science.1103336 |
| Citation | Hwang ES, et al. (2005) T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307(5708):430-3 |
| abstractText | Cell lineage specification depends on both gene activation and gene silencing, and in the differentiation of T helper progenitors to Th1 or Th2 effector cells, this requires the action of two opposing transcription factors, T-bet and GATA-3. T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development. We report that T-bet represses Th2 lineage commitment through tyrosine kinase-mediated interaction between the two transcription factors that interferes with the binding of GATA-3 to its target DNA. These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell. |
