| First Author | Zheng Z | Year | 2012 |
| Journal | Biochem Biophys Res Commun | Volume | 428 |
| Issue | 2 | Pages | 309-14 |
| PubMed ID | 23085232 | Mgi Jnum | J:190686 |
| Mgi Id | MGI:5449470 | Doi | 10.1016/j.bbrc.2012.10.053 |
| Citation | Zheng Z, et al. (2012) Effects of matrix metalloproteinase-1 on the myogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro. Biochem Biophys Res Commun 428(2):309-14 |
| abstractText | Matrix metalloproteinase-1 (MMP-1) is a member of the family of zinc-dependent endopeptidases that are capable of degrading extracellular matrix (ECM) and certain non-matrix proteins. It has been shown that MMP-1 can enhance muscle regeneration by improving the differentiation and migration of myoblasts. However, it is still not known whether MMP-1 can promote the myogenesis of bone marrow-derived mesenchymal stem cells (BMSCs). To address this question, we isolated BMSCs from C57BL/6J mice and investigated the effects of MMP-1 on their proliferation and myogenic differentiation. Our results showed that MMP-1 treatment, which had no cytotoxic effects on BMSCs, increased the mRNA and protein levels of MyoD and desmin in a dose-dependent manner, indicating that MMP-1 promoted myogenic differentiation of BMSCs in vitro. These results suggest that BMSCs may have a therapeutic potential for treating muscular disorders. |
