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Protein Coding Gene : Ube2n ubiquitin-conjugating enzyme E2N
Primary Identifier  MGI:1934835 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  93765
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables ubiquitin conjugating enzyme activity. Involved in protein K63-linked ubiquitination. Acts upstream of or within ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in brain. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N).
PHENOTYPE: Homozygous disruption of this gene causes early embryonic lethality. Mice heterozygous for a gene trap allele show increased resistance to LPS-induced lethality while cultured immune cells display blunted LPS-inducible cytokine secretion and impaired activation of TRAF-mediated signal transduction. [provided by MGI curators]
  • synonyms:
  • ubiquitin-conjugating enzyme E2N,
  • expressed sequence BB101821,
  • AL022654,
  • expressed sequence AL022654,
  • MGI:2143895,
  • 1500026J17Rik,
  • Ube2n,
  • UBC13,
  • BB101821,
  • MGI:2144921
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

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2 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

67 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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