Primary Identifier | MGI:7488392 | Allele Type | Endonuclease-mediated |
Gene | Nf1 | Strain of Origin | C57BL/6J |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Arginine codon 1278 (CGA) was changed to proline (CCA) (p.R1278P) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the human c.3827G>C, p.Arg1276Pro mutation associated with neurofibromatosis 1 (NF1). |