Primary Identifier | MGI:1097156 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 19223 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable heme binding activity and prostaglandin-I synthase activity. Acts upstream of or within decidualization and embryo implantation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; ear; early embryo; and genitourinary system. Human ortholog(s) of this gene implicated in artery disease (multiple); cerebral infarction; colorectal adenoma; and primary pulmonary hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase). PHENOTYPE: Homozygous mutation of this gene results in increased blood urea nitrogen and creatinine levels, thickening of the aorta with age, mildly increased blood pressure, and kidney abnormalities including cysts, fibrosis, necrosis, and renal vascular congestion. [provided by MGI curators] |