| First Author | Faunce DE | Year | 2001 |
| Journal | J Immunol | Volume | 166 |
| Issue | 1 | Pages | 313-21 |
| PubMed ID | 11123307 | Mgi Jnum | J:66399 |
| Mgi Id | MGI:1928420 | Doi | 10.4049/jimmunol.166.1.313 |
| Citation | Faunce DE, et al. (2001) MIP-2 recruits NKT cells to the spleen during tolerance induction. J Immunol 166(1):313-21 |
| abstractText | Peripheral tolerance occurs after intraocular administration of Ag and is dependent on an increase in splenic NKT cells. New data here show that macrophage inflammatory protein-2 (MIP-2) is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. |
