| First Author | Yasukawa K | Year | 2002 |
| Journal | Biol Pharm Bull | Volume | 25 |
| Issue | 11 | Pages | 1488-90 |
| PubMed ID | 12419967 | Mgi Jnum | J:80318 |
| Mgi Id | MGI:2445657 | Doi | 10.1248/bpb.25.1488 |
| Citation | Yasukawa K, et al. (2002) Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Biol Pharm Bull 25(11):1488-90 |
| abstractText | Four steviol (ent-kaurene-type diterpenoid) glycosides, stevioside, rebaudiosides A and C, and dulcoside A, have been isolated from Stevia rebaudiana BERTONI. These compounds showed strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 54.1-291.6 micro g/ear. Furthermore, at 1.0 and 0.1 mg/mouse of stevioside mixture, the mixture of these compounds markedly inhibited the promoting effect of TPA (1 micro g/mouse) on skin tumor formation initiated with 7,12-dimethylbenz[a]anthracene (50 micro g/mouse). |
