| First Author | Egaas E | Year | 1995 |
| Journal | Comp Biochem Physiol C Pharmacol Toxicol Endocrinol | Volume | 110 |
| Issue | 1 | Pages | 35-40 |
| PubMed ID | 7749601 | Mgi Jnum | J:26954 |
| Mgi Id | MGI:74377 | Doi | 10.1016/0742-8413(94)00079-p |
| Citation | Egaas E, et al. (1995) A study of gender, strain and age differences in mouse liver glutathione-S-transferase. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 110(1):35-40 |
| abstractText | The hepatic cytosolic glutathione S-transferase (GST) activity in four strains of the mouse and one strain of the rat was studied with the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), ethachrynic acid (ETHA), cumene hydroperoxide (CU) and atrazine as the in vitro substrates. In the mouse, significant gender, strain and age-related differences in the GST activity towards CDNB and atrazine were found between adolescent and sexually mature males and females of the CD-1, C57BL/6, DBA/2 and Swiss-Webster strains, and the differences were larger with atrazine as the substrate. With DCNB and CU a similar tendency was observed, however not significant for all strains. The GST activity towards ETHA was also gender and strain specific, but revealed no age-related differences. The herbicide atrazine seems to be a useful substrate in the study of strain and age-related differences in the mouse GST class Pi. |
