| Primary Identifier | MGI:2136643 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Irs1 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A PGK-neomycin cassette disrupted the first exon of the gene, preventing the production of stable mRNA transcripts. No transcript was detected in hepatic tissues of homozygous null mice by Northern blot analysis. Western blots of liver homogenates showed no detectable protein. |
