| First Author | Savitsky D | Year | 2006 |
| Journal | J Exp Med | Volume | 203 |
| Issue | 10 | Pages | 2305-14 |
| PubMed ID | 16954370 | Mgi Jnum | J:124626 |
| Mgi Id | MGI:3722044 | Doi | 10.1084/jem.20060411 |
| Citation | Savitsky D, et al. (2006) B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion. J Exp Med 203(10):2305-14 |
| abstractText | B-1 B cells produce circulating natural antibodies that provide 'innate-like' protection against bacterial and viral pathogens. They also provide adaptive responses to blood and air-borne pathogens. B lymphocyte-induced maturation protein 1 (Blimp-1) is a transcriptional repressor that is required for the formation of B-2-derived antibody-secreting plasma cells. In this study, we used mice lacking Blimp-1 in the B cell lineage to show that Blimp-1 is not necessary for the formation or self-renewal of B-1 B cells but that Blimp-1 is required for normal immunoglobulin (Ig) secretion by B-1 cells. B-1 cells lacking Blimp-1 do not repress Pax5 mRNA and do not induce X-box binding protein 1, and mu secreted mRNA normally, showing that B-1 and B-2 cells both use a common pathway for Ig secretion. Blimp-1-deficient B-1 B cells are also defective in providing early protection against influenza infection. |
