| First Author | Zhao Z | Year | 2017 |
| Journal | FASEB J | Volume | 31 |
| Issue | 11 | Pages | 4903-4916 |
| PubMed ID | 28729290 | Mgi Jnum | J:254422 |
| Mgi Id | MGI:6108520 | Doi | 10.1096/fj.201700533R |
| Citation | Zhao Z, et al. (2017) Choroidal gammadelta T cells in protection against retinal pigment epithelium and retinal injury. FASEB J 31(11):4903-4916 |
| abstractText | gammadelta T cells located near the epithelial barrier are integral components of local inflammatory and innate immune responses. We have previously reported the presence of choroidal gammadelta T cells in a model of chronic degeneration of the retinal pigment epithelium (RPE). The goals of the current study were to further define the functions of choroidal gammadelta T cells and to explore the underlying mechanisms of their action. Our data demonstrate that choroidal gammadelta T cells are activated by RPE injury in response to NaIO3 treatment, and that they express genes that encode immunosuppressive cytokines, such as IL-4 and IL-10. gammadelta-T-cell-deficient mice developed profound RPE and retinal damage at doses that caused minimal effects in wild-type mice, and adoptive transfer of gammadelta T cells prevented sensitization. Intravitreal injection of IL-4 and IL-10 ameliorated RPE toxicity that was induced by NaIO3Ex vivo coculture of gammadelta T cells with RPE explants activated the production of anti-inflammatory cytokines via an aryl hydrocarbon receptor (AhR)-dependent mechanism. AhR deficiency abolished the protective effects of gammadelta T cells after adoptive transfer. Collectively, these findings define important roles for choroid gammadelta T cells in maintaining tissue homeostasis in the outer retina.-Zhao, Z., Liang, Y., Liu, Y., Xu, P., Flamme-Wiese, M. J., Sun, D., Sun, J., Mullins, R. F., Chen, Y., Cai, J. Choroidal gammadelta T cells in protection against retinal pigment epithelium and retinal injury. |
