| First Author | Gabriel G | Year | 2015 |
| Journal | J Infect Dis | Volume | 212 Suppl 2 |
| Pages | S316-21 | PubMed ID | 26185094 |
| Mgi Jnum | J:292882 | Mgi Id | MGI:6451306 |
| Doi | 10.1093/infdis/jiv240 | Citation | Gabriel G, et al. (2015) Importin-alpha7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice. J Infect Dis 212 Suppl 2:S316-21 |
| abstractText | Ebola virus (EBOV) protein 24 antagonizes the host interferon (IFN) response by hijacking select nuclear importin-alpha isoforms. Thereby, it blocks STAT1-mediated IFN-alpha/beta and IFN-gamma synthesis. However, owing to the lack of importin-alpha knockout animal models in the past, their role in EBOV pathogenesis remained largely unknown. Here, we demonstrate that importin-alpha7 is involved in the formation of EBOV inclusion bodies and replication. However, deletion of the gene encoding importin-alpha7 was not sufficient to increase survival rates among mice infected with EBOV. |
