| First Author | Zhou R | Year | 2009 |
| Journal | Cell | Volume | 139 |
| Issue | 4 | Pages | 802-13 |
| PubMed ID | 19914172 | Mgi Jnum | J:154859 |
| Mgi Id | MGI:4410392 | Doi | 10.1016/j.cell.2009.10.023 |
| Citation | Zhou R, et al. (2009) KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. Cell 139(4):802-13 |
| abstractText | The kinesin superfamily proteins (KIFs) are motor proteins that transport organelles and protein complexes in a microtubule- and ATP-dependent manner. We identified KIF26A as a new member of the murine KIFs. KIF26A is a rather atypical member as it lacks ATPase activity. Mice with a homozygous deletion of Kif26a developed a megacolon with enteric nerve hyperplasia. Kif26a-/- enteric neurons showed hypersensitivity for GDNF-Ret signaling, and we find that KIF26A suppressed GDNF-Ret signaling by direct binding and inhibition of Grb2, an essential component of GDNF/Akt/ERK signaling. We therefore propose that the unconventional kinesin KIF26A plays a key role in enteric nervous system development by repressing a cell growth signaling pathway. |
