| Primary Identifier | IPR042972 | Type | Family |
| Short Name | INSM1/2 |
| description | Insulinoma-associated protein 1 (INSM1) is a zinc-finger transcription factor exclusively expressed in the foetal pancreas and nervous system, and in tumours of neuroendocrine origin. It can recruits cyclin D1 and HDACs, which confer transcriptional repressor activity []. It is involved in endocrine and neuronal cell differentiation []. In pancreas, it is activated by the islet-specific endocrine factor neurogenin 3, and subsequently regulates downstream target genes NeuroD1 and insulin during beta-cell maturation [].Transcription factor egl-46 is the C. elegans orthologue from human INSM2, which is involved in neuron differentiation []. |
