| First Author | Byerly MS | Year | 2013 |
| Journal | Eur J Neurosci | Volume | 37 |
| Issue | 7 | Pages | 1033-47 |
| PubMed ID | 23360481 | Mgi Jnum | J:214924 |
| Mgi Id | MGI:5604212 | Doi | 10.1111/ejn.12122 |
| Citation | Byerly MS, et al. (2013) Estrogen-related receptor beta deletion modulates whole-body energy balance via estrogen-related receptor gamma and attenuates neuropeptide Y gene expression. Eur J Neurosci 37(7):1033-47 |
| abstractText | Estrogen-related receptors (ERRs) alpha, beta and gamma are orphan nuclear hormone receptors with no known ligands. Little is known concerning the role of ERRbeta in energy homeostasis, as complete ERRbeta-null mice die mid-gestation. We generated two viable conditional ERRbeta-null mouse models to address its metabolic function. Whole-body deletion of ERRbeta in Sox2-Cre:ERRbeta(lox/lox) mice resulted in major alterations in body composition, metabolic rate, meal patterns and voluntary physical activity levels. Nestin-Cre:ERRbeta(lox/lox) mice exhibited decreased expression of ERRbeta in hindbrain neurons, the predominant site of expression, decreased neuropeptide Y (NPY) gene expression in the hindbrain, increased lean body mass, insulin sensitivity, increased energy expenditure, decreased satiety and decreased time between meals. In the absence of ERRbeta, increased ERRgamma signaling decreased satiety and the duration of time between meals, similar to meal patterns observed for both the Sox2-Cre:ERRbeta(lox/lox) and Nestin-Cre:ERRbeta(lox/lox) strains of mice. Central and/or peripheral ERRgamma signaling may modulate these phenotypes by decreasing NPY gene expression. Overall, the relative expression ratio between ERRbeta and ERRgamma may be important in modulating ingestive behavior, specifically satiety, gene expression, as well as whole-body energy balance. |
