| First Author | Miccoli L | Year | 2007 |
| Journal | Cancer Res | Volume | 67 |
| Issue | 10 | Pages | 4695-9 |
| PubMed ID | 17510396 | Mgi Jnum | J:121733 |
| Mgi Id | MGI:3711396 | Doi | 10.1158/0008-5472.CAN-06-3844 |
| Citation | Miccoli L, et al. (2007) The combined effects of xeroderma pigmentosum C deficiency and mutagens on mutation rates in the mouse germ line. Cancer Res 67(10):4695-9 |
| abstractText | Spontaneous and induced mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germ line of xeroderma pigmentosum group C (Xpc) knockout mice defective in global genome nucleotide excision repair. Spontaneous and radiation-induced mutation rates in homozygous Xpc(-/-) males were significantly higher than those in isogenic wild-type (Xpc(+/+)) and heterozygous (Xpc(+/-)) mice. In contrast, exposure to the monofunctional alkylating agent ethylnitrosourea resulted in similar increases in ESTR mutation rates across all genotypes. ESTR mutation spectra in the germ line of Xpc(-/-), Xpc(+/-) and Xpc(+/+) did not differ. Considering these data and the results of other publications, we propose that the Xpc-deficient mice possess a mutator phenotype in their germ line and somatic tissues that may significantly enhance carcinogenesis across multiple tissues. |
