| Primary Identifier | MGI:1928486 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 56720 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Predicted to be involved in protein homotetramerization; tryptophan catabolic process to acetyl-CoA; and tryptophan catabolic process to kynurenine. Predicted to act upstream of or within tryptophan catabolic process. Is expressed in cerebellum; liver; male reproductive gland or organ; and small intestine. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased plasma and brain levels of tryptophan, increased serotonin levels in the brain, decreased anxiety-related behavior, increased neuronal precursor proliferation and accelerated neurogenesis in the granule cell layer of the olfactory bulb. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
