| Primary Identifier | IPR037435 | Type | Family |
| Short Name | 14-3-3_sigma |
| description | 14-3-3 protein sigma isoform, also known as stratifin or human mammary epithelial marker (HME) 1, has been most directly linked to tumour development [, ]. In humans, it is expressed by the SFN gene, strictly in stratified squamous epithelial cells in response to DNA damage where it is transcriptionally induced in a p53-dependent manner, subsequently causing cell-cycle arrest at the G2/M checkpoint []. Up-regulation and down-regulation of 14-3-3 sigma expression have both been described in tumours. For example, in human breast cancer, 14-3-3 sigma is predominantly down-regulated by CpG methylation, acting as both a tumour suppressor and a prognostic indicator [], while in human scirrhous-type gastric carcinoma (SGC), it is up-regulated and may play an important role in SGC carcinogenesis and progression []. Loss of 14-3-3 sigma expression sensitizes tumour cells to treatment with conventional cytostatic drugs, making this protein an attractive therapeutic target []. |
