| First Author | Andreani V | Year | 2023 |
| Journal | J Exp Med | Volume | 220 |
| Issue | 1 | PubMed ID | 36350325 |
| Mgi Jnum | J:332530 | Mgi Id | MGI:7424775 |
| Doi | 10.1084/jem.20220342 | Citation | Andreani V, et al. (2023) Integrin beta1 regulates marginal zone B cell differentiation and PI3K signaling. J Exp Med 220(1) |
| abstractText | Marginal zone (MZ) B cells represent innate-like B cells that mediate a fast immune response. The adhesion of MZ B cells to the marginal sinus of the spleen is governed by integrins. Here, we address the question of whether beta1-integrin has additional functions by analyzing Itgb1fl/flCD21Cre mice in which the beta1-integrin gene is deleted in mature B cells. We find that integrin beta1-deficient mice have a defect in the differentiation of MZ B cells and plasma cells. We show that integrin beta1-deficient transitional B cells, representing the precursors of MZ B cells, have enhanced B cell receptor (BCR) signaling, altered PI3K and Ras/ERK pathways, and an enhanced interaction of integrin-linked kinase (ILK) with the adaptor protein Grb2. Moreover, the MZ B cell defect of integrin beta1-deficient mice could, at least in part, be restored by a pharmacological inhibition of the PI3K pathway. Thus, beta1-integrin has an unexpected function in the differentiation and function of MZ B cells. |
