Primary Identifier | MGI:1100860 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 327826 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within several processes, including camera-type eye development; nervous system development; and regulation of MAPK cascade. Located in cell-cell junction; cytoplasm; and plasma membrane. Is expressed in several structures, including blastocyst; central nervous system; genitourinary system; gut; and immune system. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2). PHENOTYPE: Homozygous null mice exhibit embryonic lethality between E5.75 and E8 and defects in primitive streak formation and anterior-posterior axis formation. [provided by MGI curators] |