Primary Identifier | MGI:1914878 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 67628 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable RNA polymerase binding activity and histone binding activity. Acts upstream of or within several processes, including inner ear development; roof of mouth development; and ventricular system development. Located in nucleus. Is expressed in several structures, including cerebral cortex ventricular layer; eye; heart; metanephros; and upper jaw. Orthologous to human ANP32B (acidic nuclear phosphoprotein 32 family member B). PHENOTYPE: Mice homozygous for a knock-out allele exhibit background-sensitive partial perinatal lethality with failure to initiate breathing, craniofacial defects, enlarged brain ventricle, expanded inner ear cavities, plate closure defects, decreased body weight, premature aging, and premature death. [provided by MGI curators] |