| First Author | Van Nuffel E | Year | 2018 |
| Journal | J Invest Dermatol | Volume | 138 |
| Issue | 9 | Pages | 1903-1905 |
| PubMed ID | 30143077 | Mgi Jnum | J:266330 |
| Mgi Id | MGI:6202794 | Doi | 10.1016/j.jid.2018.05.001 |
| Citation | Van Nuffel E, et al. (2018) Psoriasis Plays a Wild CARD. J Invest Dermatol 138(9):1903-1905 |
| abstractText | Rare autosomal mutations in CARD14 have previously been linked to psoriasis susceptibility in humans, but their pathogenic role had not been shown. Mellett et al. generated mice harboring the patient-derived gain-of-function Card14DeltaE138 mutation and showed that hyperactivation of CARD14 alone is sufficient to induce immunopathogenic mechanisms that are responsible for psoriasis, which is driven by the IL-17/IL-23 axis. |
