| Type | MGI:General | Description | at >E12.5, homozygotes fail to exhibit an exponential expansion of insulin-expressing cells in the pancreas, with only a few mature beta cells detected at E18.5, indicating a specific blockage during the secondary phase of beta-cell neogenesis unlike Nkx2-2tm1Jlr homozygotes, Nkx6-1tm1Jlr mutant embryos do not accumulate incompletely differentiated beta-cell precursors but display decreased beta-cell neogenesis due to loss of late stage precursors in the absence of increased beta-cell apoptosis |
