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Allele : Grm2<tm1Ddsc> glutamate receptor, metabotropic 2; targeted mutation 1, Darryle D Schoepp

Primary Identifier	MGI:3665323	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Grm2
Transmission	Germline	Strain of Origin	(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase	false	Is Wild Type	false

molecularNote

A neomycin resistance gene replaced most of the third exon that encodes for a large portion of the ligand-binding domain.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
mGlu2<->,
mGlu2<->,
mGluR2-KO,
mGluR2-KO

earliestPublication:
Linden AM, et al. (2005) Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice. Psychopharmacology (Berl) 179(1):284-91

1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

13 Publication categories

Trail: Allele

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MouseMine

Allele : Grm2<tm1Ddsc> glutamate receptor, metabotropic 2; targeted mutation 1, Darryle D Schoepp

External Links

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

13 Publication categories