| First Author | de Pooter RF | Year | 2019 |
| Journal | J Immunol | Volume | 202 |
| Issue | 10 | Pages | 2837-2842 |
| PubMed ID | 30962294 | Mgi Jnum | J:274901 |
| Mgi Id | MGI:6296870 | Doi | 10.4049/jimmunol.1801220 |
| Citation | de Pooter RF, et al. (2019) Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1. J Immunol 202(10):2837-2842 |
| abstractText | Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia. |
