| First Author | Gaudet F | Year | 2003 |
| Journal | Science | Volume | 300 |
| Issue | 5618 | Pages | 489-92 |
| PubMed ID | 12702876 | Mgi Jnum | J:82979 |
| Mgi Id | MGI:2656402 | Doi | 10.1126/science.1083558 |
| Citation | Gaudet F, et al. (2003) Induction of tumors in mice by genomic hypomethylation. Science 300(5618):489-92 |
| abstractText | Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of tumorigenesis has been unclear. To explore this phenomenon, we generated mice carrying a hypomorphic DNA methyltransferase 1 (Dnmt1) allele, which reduces Dnmt1 expression to 10% of wild-type levels and results in substantial genome-wide hypomethylation in all tissues. The mutant mice were runted at birth, and at 4 to 8 months of age they developed aggressive T cell lymphomas that displayed a high frequency of chromosome 15 trisomy. These results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability. |
