| First Author | Rudy CK | Year | 1992 |
| Journal | J Exp Med | Volume | 175 |
| Issue | 6 | Pages | 1613-21 |
| PubMed ID | 1316931 | Mgi Jnum | J:876 |
| Mgi Id | MGI:49409 | Doi | 10.1084/jem.175.6.1613 |
| Citation | Rudy CK, et al. (1992) Mls-1-like superantigen in the MA/MyJ mouse is encoded by a new mammary tumor provirus that is distinct from Mtv-7. J Exp Med 175(6):1613-21 |
| abstractText | Mls-1 is an endogenous superantigen that leads to in vivo deletion and in vitro stimulation of T cell receptor (TCR) V beta 6-, 7-, 8.1-, and 9-expressing cells. The MA/MyJ mouse deletes the identical set of TCR from its mature T cell repertoire; however, it does not contain Mtv-7, the murine mammary tumor provirus (MMTV), whose sag gene encodes Mls-1. Interestingly, the superantigen activity of this mouse strain segregates with a new mammary tumor provirus, Mtv-43, not seen in other inbred strains. The predicted amino acid sequence of the sag gene of Mtv-43 was compared with that of Mtv-7. Strikingly, the COOH terminus of the two molecules is very similar, while all other MMTV-encoded superantigens differ 100% in this segment. |
