| Primary Identifier | MGI:5910041 | Allele Type | Chemically induced (ENU) |
| Attribute String | Dominant negative, Null/knockout | Gene | Kctd1 |
| Inheritance Mode | Dominant | Strain of Origin | C3HeB/FeJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The molecular lesion responsible for the phenotype is a point mutation resulting in a T-to-A transversion at nucleotide 80 (ENSMUST00000025992.6, 265-amino-acid isoform), leading to an amino acid exchange from isoleucine to asparagine at position 27, thereby affecting the functional BTB domain of the protein. The mutation presumably causes a loss of function via a dominant-negative mechanism. |
