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Protein Coding Gene : Gjb3 gap junction protein, beta 3
Primary Identifier  MGI:95721 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  14620
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable gap junction channel activity. Acts upstream of or within placenta development. Located in cytoplasm and gap junction. Is expressed in several structures, including alimentary system; early conceptus; integumental system; reproductive system; and sensory organ. Used to study erythrokeratodermia variabilis. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and erythrokeratodermia variabilis. Orthologous to human GJB3 (gap junction protein beta 3).
PHENOTYPE: Homozygous null mice exhibit partial lethality and transient placental dysmorphogenesis but no impairment in hearing or skin differentiation. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-10098,
  • connexin 31,
  • Gjb3,
  • D4Wsu144e,
  • MGD-MRK-35792,
  • Cnx31,
  • MGI:107326,
  • gap junction protein, beta 3,
  • Gjb-3,
  • MGD-MRK-10093,
  • DNA segment, Chr 4, Wayne State University 144, expressed,
  • Cx31
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