| First Author | Kawabata H | Year | 2006 |
| Journal | Int Immunol | Volume | 18 |
| Issue | 1 | Pages | 183-98 |
| PubMed ID | 16352628 | Mgi Jnum | J:104156 |
| Mgi Id | MGI:3611401 | Doi | 10.1093/intimm/dxh361 |
| Citation | Kawabata H, et al. (2006) Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease. Int Immunol 18(1):183-98 |
| abstractText | CD8(+) CTLs and virus-neutralizing antibodies have been associated with spontaneous and vaccine-induced immune control of retroviral infections. We previously showed that a single immunization with an env gene-encoded CD4(+) T cell epitope protected mice against fatal Friend retrovirus infection. Here, we analyzed immune cell components required for the peptide-induced anti-retroviral protection. Mice lacking CD8(+) T cells were nevertheless protected against Friend virus infection, while mice lacking B cells were not. Virus-producing cells both in the spleen and bone marrow decreased rapidly in their number and became undetectable by 4 weeks after infection in the majority of the peptide-immunized animals even in the absence of CD8(+) T cells. In the vaccinated animals the production and class switching of virus-neutralizing and anti-leukemia cell antibodies were facilitated; however, virus-induced erythroid cell expansion was suppressed before neutralizing antibodies became detectable in the serum. Further, the numbers of virus-producing cells in the spleen and bone marrow in the early stage of the infection were smaller in the peptide-immunized than in unimmunized control mice in the absence of B cells. Thus, peptide immunization facilitates both early cellular and late humoral immune responses that lead to the effective control of the retrovirus-induced disease, but CD8(+) T cells are not crucial for the elimination of virus-infected cells in the peptide-primed animals. |
