| Primary Identifier | MGI:3522655 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Ovgp1-TAg)1Imiy |
| Strain of Origin | (C57BL/6 x DBA/2)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | The transgenic line was maintained in the paternal germline since transgenic females developed severe uterine tumor pathology by 6 weeks of age. A small number of males greater than 6 months of age developed prostate tumors. |
| molecularNote | The SV40 large T antigen was placed under the transcriptional control of a 2.2 kb fragment containing the mouse oviductal glycoprotein 1 (Ovgp1) gene promoter sequence. 3' UTR and polyA sequences were derived from the rabbit Beta globin gene. RT-PCR confirmed SV40 TAg expression in the oviduct, uterus, vagina, and ovary, but not in the brain, lung, heart, liver, kidney, spleen, stomach, muscle, spinal cord, lymph node, mammary gland, or fat tissue. |
