| First Author | Brand MD | Year | 2005 |
| Journal | Biochem J | Volume | 392 |
| Issue | Pt 2 | Pages | 353-62 |
| PubMed ID | 16076285 | Mgi Jnum | J:117573 |
| Mgi Id | MGI:3696914 | Doi | 10.1042/BJ20050890 |
| Citation | Brand MD, et al. (2005) The basal proton conductance of mitochondria depends on adenine nucleotide translocase content. Biochem J 392(Pt 2):353-62 |
| abstractText | The basal proton conductance of mitochondria causes mild uncoupling and may be an important contributor to metabolic rate. The molecular nature of the proton-conductance pathway is unknown. We show that the proton conductance of muscle mitochondria from mice in which isoform 1 of the adenine nucleotide translocase has been ablated is half that of wild-type controls. Overexpression of the adenine nucleotide translocase encoded by the stress-sensitive B gene in Drosophila mitochondria increases proton conductance, and underexpression decreases it, even when the carrier is fully inhibited using carboxyatractylate. We conclude that half to two-thirds of the basal proton conductance of mitochondria is catalysed by the adenine nucleotide carrier, independently of its ATP/ADP exchange or fatty-acid-dependent proton-leak functions. |
