First Author | Basu R | Year | 2018 |
Journal | Eur J Endocrinol | Volume | 178 |
Issue | 5 | Pages | R155-R181 |
PubMed ID | 29459441 | Mgi Jnum | J:310349 |
Mgi Id | MGI:6761641 | Doi | 10.1530/EJE-18-0018 |
Citation | Basu R, et al. (2018) MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?. Eur J Endocrinol 178(5):R155-R181 |
abstractText | Growth hormone (GH) is produced primarily by anterior pituitary somatotroph cells. Numerous acute human (h) GH treatment and long-term follow-up studies and extensive use of animal models of GH action have shaped the body of GH research over the past 70 years. Work on the GH receptor (R)-knockout (GHRKO) mice and results of studies on GH-resistant Laron Syndrome (LS) patients have helped define many physiological actions of GH including those dealing with metabolism, obesity, cancer, diabetes, cognition and aging/longevity. In this review, we have discussed several issues dealing with these biological effects of GH and attempt to answer the question of whether decreased GH action may be beneficial. |