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Protein Coding Gene : Nrg3 neuregulin 3

Primary Identifier  MGI:1097165 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  18183
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables chemorepellent activity. Involved in ERBB4-ERBB4 signaling pathway and synapse assembly. Acts upstream of or within several processes, including intracellular signal transduction; mammary placode formation; and regulation of cell migration. Is active in extracellular space and glutamatergic synapse. Is expressed in several structures, including embryo mesenchyme; epidermis; mammary gland primordium; nervous system; and testis. Used to study schizophrenia. Orthologous to human NRG3 (neuregulin 3).
PHENOTYPE: Mutations in this gene result in abnormal, genetic background specific, mammary gland development. Male mice homozygous for a knock-out allele show novelty-induced hyperactivity, decreased prepulse inhibition, and impaired cued conditioning behavior. [provided by MGI curators]
  • synonyms:
  • MGI:1354957,
  • ska,
  • scaramanga,
  • neuregulin 3,
  • Nrg3

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

21 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For